在八爪，文献还可以这样读！8月11日365卷第6期的这期NEJM，你不能错过的医学前沿进展！
【原始论文】
1. HIV- 1感染的预防与早期抗逆转录病毒疗法
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
[评论] 抗逆转录病毒治疗作为预防
Antiretroviral Treatment as Prevention
2. 成人危重患者的早期与晚期肠外营养
Early versus Late Parenteral Nutrition in Critically Ill Adults
[评论] 重大疾病的营养支持 – 弥合证据差距
Nutrition Support in Critical Illness — Bridging the Evidence Gap
3. 在感染胸腔使用组织型纤溶酶原激活剂和DNase
Intrapleural Use of Tissue Plasminogen Activator and DNase in Pleural Infection
4. Linaclotide治疗慢性便秘的两个随机试验
Two Randomized Trials of Linaclotide for Chronic Constipation
5. 利伐沙班对比华法林治疗房颤
Rivaroxaban vs. Warfarin in Atrial Fibrillation
[评论] 房颤抗凝治疗中的新选择
New Options in Anticoagulation for Atrial Fibrillation
【综述】
**发病机制：氧感应、动态平衡与疾病
** Mechanisms of Disease: Oxygen Sensing, Homeostasis, and Disease
【MGH病例报道】
**一个36岁的男子伴有头痛，记忆力减退和混乱
** Case 24-2011 — A 36-Year-Old Man with Headache, Memory Loss, and Confusion
【基础研究的临床意义】
**癌症恶病质和脂肪-肌肉生理学
** Cancer Cachexia and Fat–Muscle Physiology
【观察】
1. 贝特类药物治疗血脂异常 -到了 重新评估的时候
Fibrates in the Treatment of Dyslipidemias — Time for a Reassessment
**2. 神秘的“神秘顾客”的研究
** Taking the Mystery out of “Mystery Shopper” Studies
Incomplete Care — On the Trail of Flaws in the System
4. 医学史：复方药物 – 炒作，危害和希望
History of Medicine: Combination Drugs — Hype, Harm, and Hope
【临床图片】
1. 指尖疣 Warts of the Fingertips
2. 固定型药疹 Fixed Drug Eruption