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八爪，让悦读NEJM成为习惯。今天是元宵节，无论是元宵，还是甜甜圈，都不能错过364卷第7期的这本NEJM！

想知道“甜甜圈洞”是什么以及这个洞怎么补吗？特发性肾病又有什么新进展？贝伐单抗能否给早产儿视网膜病变带来福音？各种精彩，尽在本期NEJM……

【原始论文】

1.早产儿3+期视网膜病变玻璃体内注射贝伐单抗的疗效 Efficacy of Intravitreal Bevacizumab for Stage 3+ Retinopathy of Prematurity

2.HLA-DQA1 及PLA2R1等位基因与特发性膜性肾病Risk HLA-DQA1 and PLA2R1 Alleles in Idiopathic Membranous Nephropathy

3.神经胶质细胞瘤中NFKBIA的缺失NFKBIA Deletion in Glioblastomas

4.中国H1N1疫苗上市后的安全性监测 Safety of Influenza A (H1N1) Vaccine in Postmarketing Surveillance in China

【社论】

1.贝伐单抗治疗早产儿视网膜病Bevacizumab for Retinopathy of Prematurity

2.联系自身免疫与肾炎的基因Genes That Link Nephritis to Autoantibodies and Innate Immunity

【临床实践】

链球菌咽炎 Streptococcal Pharyngitis

【综述】

疾病的机制——缺氧与炎症的关系Hypoxia and Inflammation

【MGH病例报道】

65岁男性前列腺癌治疗后出现血尿 Case 5-2011 — A 65-Year-Old Man with Hematuria after Treatment for Prostate Cancer

【观察】

1. 医疗保险中终末期肾病的捆绑付费模式Bundled Payment for ESRD — Including ESAs in Medicare’s Dialysis Package

2.特殊治疗——终末期肾病获保的故事Special Treatment — The Story of Medicare’s ESRD Entitlement

3. 医改与联邦老人医疗保险D部分——“甜甜圈洞”的填补需要时间Time to Fill the Doughnuts — Health Care Reform and Medicare Part D

4.医学学术中心中的医疗负责机构Accountable Care Organizations at Academic Medical Centers

5.以约翰霍普金斯为榜样——医学学术中心中医疗负责制的建立Accountable Care at Academic Medical Centers — Lessons from Johns Hopkins

【临床图片】

1. 杵状指与发绀Differential Clubbing and Cyanosis

2.溶栓治疗后舌血肿Lingual Hematoma after Thrombolytic Therapy

【通讯】

1.冠心病中氯吡格雷与奥美拉唑的治疗作用Clopidogrel with or without Omeprazole in Coronary Disease

2.HIV感染者肾移植的预后Outcomes of Kidney Transplantation in HIV-Infected Recipients

3.医保中病人受害率的变化趋势Temporal Trends in Rates of Patient Harm from Medical Care

4.阿片类药物与死亡Opioids and Deaths

5.全身放疗对骨软骨瘤的作用Osteochondromas after Total-Body Irradiation

6.长期应用贝伐单抗治疗遗传性出血性毛细血管扩张症Long-Term Therapy with Bevacizumab in Hereditary Hemorrhagic Telangiectasia

7.PLA2R自身抗体及膜性肾病中PLA2R沉积PLA2R Autoantibodies and PLA2R Glomerular Deposits in Membranous Nephropathy