八爪悦读，创造幸福！送上这期2月23日366卷第8期的新鲜NEJM。
【原始论文】
1. 结肠镜切除息肉和肠癌的长期预防**
Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths
[评论] 以结肠镜作为肠癌的分流筛查
Colonoscopy as a Triage Screening Test
2. **肠癌筛查的结**肠镜与便免疫组化检查对比**
Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening
3. Vemurafenib治疗晚期**BRAF V600突变的黑色素瘤的存活**
Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
4. 简报：三例完整面部移植患者
Brief Report: Three Patients with Full Facial Transplantation
【MGH病例报道】
45岁酗酒男性出现快速认知下降
Case 6-2012 — A 45-Year-Old Man with a History of Alcohol Abuse and Rapid Cognitive Decline
【临床实践】
扁平苔藓
【综述】
基因组学、智力残疾与自闭症
Genomic Medicine: Genomics, Intellectual Disability, and Autism(免费全文)
[评论] 实现医疗基因组学
Realizing Genomic Medicine(免费全文)
【基础研究的临床意义】
反义治疗在脊髓性肌萎缩症中的意义
Sense in Antisense Therapy for Spinal Muscular Atrophy
【观察】
1. 保护赴战人员——非战争引起的患病率和命令责任
Protecting Service Members in War — Non-Battle Morbidity and Command Responsibility
2. 成为一名医生：生命原来是这样
Becoming a Physician: What Life Is Like
3. NEJM200周年纪念文章：病人和医生——关系的演变
200th Anniversary Article: Patients and Doctors — The Evolution of a Relationship(免费全文)
4. 当我们谈医疗费用时我们在谈论什么
What We Talk about When We Talk about Health Care Costs(免费全文)
5. 准备精密医学
Preparing for Precision Medicine(免费全文)
【临床图片】
1. 与结肠镜检查相关的乙状结肠穿孔 Sigmoid Perforation in Association with Colonoscopy (免费全文)
2 蜘蛛痣 Spider Angioma (免费全文)