八爪悦读，创造幸福！1月19日366卷第3期的新鲜NEJM，很值得看的医学前沿进展！
【原始论文】
1. 皮肤鳞状细胞癌患者中接受BRAF抑制剂治疗的RAS基因突变
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
[评论] 环绕边缘——BRAF抑制剂的悖论
RAF around the Edges — The Paradox of BRAF Inhibitors
2. 丙肝基因型1的抗病毒药物的两个初步研究
Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1
[评论] 丙型肝炎治疗的分水岭时刻
A Watershed Moment in the Treatment of Hepatitis C
3. 老年女性骨质疏松的骨密度测试间隔与转型
Bone-Density Testing Interval and Transition to Osteoporosis in Older Women
4. **非上皮卵巢癌的反复DICER1体基因突变**
Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers
5. 简报：甲状腺激素受体的α基因突变
Brief Report: A Mutation in the Thyroid Hormone Receptor Alpha Gene
【MGH病例报道】
63岁女性出现呼吸困难及进行性的呼吸衰竭
Case 2-2012 — A 63-Year-Old Woman with Dyspnea and Rapidly Progressive Respiratory Failure
【综述】
当前概念：冠脉搭桥术后的认知与神经系统预后
Current Concepts: Cognitive and Neurologic Outcomes after Coronary-Artery Bypass Surgery
【观察】
1. 减轻痛苦101——止痛在美国
Alleviating Suffering 101 — Pain Relief in the United States
2. 痛苦的不公平现象——发展中国家姑息治疗
Painful Inequities — Palliative Care in Developing Countries
3. 阿托伐他汀和医疗保健费用
Generic Atorvastatin and Health Care Cost(免费全文)
【临床图片】
1. 椎体术后的肺栓塞 Pulmonary Cement Embolism after Vertebroplasty (免费全文)
2.Tophaceous痛风 Tophaceous Gout(免费全文)